It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease. A dense diffuse or nodular infiltrate in the dermis characterized by. In 1906 jadassohn 1 presented before the ninth german dermatological congress the first case of what was later to be known as lymphocytoma cutis. In contrast to other cbcls, primary cutaneous marginal zone bcell lymphoma pcmzl contains plasmacytoid dendritic cells pdcs arranged in larger clusters. Borrelia burgdorferi infection and cutaneous lyme disease. The many faces of lymphocytoma cutis van vloten 2003 journal. Cutaneous pseudolymphomas are a group of benign reactive t or b cell lymphoproliferative processes of diverse etiology that simulate. In endemic regions, borrelia burgdorferi is the principal causative agent for lc. The etiopathogenesis of primary cutaneous bcell lymphomas cbcls is still to be elucidated. Lymphocytoma cutis following excision arthroplasty mehta v. This redirect is within the scope of wikiproject medicine. Four patients who had received tick bites while visiting forests in mexico had skin lesions that met the case definition of erythema migrans, or borrelial lymphocytoma. Atypical location of lymphocytoma cutis in a child. In 1923, bilerstein coined term lymphocytoma cutis term lymphadenosis benigna cutis was introduced by bafverstedt in 1943 in 1967, lever introduced term pseudolymphoma of spiegler and fendt subsequently,caro and helwig in 1969 introduced term.
Apr 29, 2016 lymphocytoma cutis is a subtype of cutaneous pseudolymphoma involving the face, chest, and upper extremities. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Pdf we describe a clinical case involving a 62yearold white male. Please visit the project page for details or ask questions at wikipedia talk. Lymphocytoma cutis, or spieglerfendt sarcoid, is classed as one of the pseudolymphonas, 1 referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Over 10 million scientific documents at your fingertips. It clinically presents as skincolored to darkred papules, nodules, or infiltrative plaques similar in appearance to cutaneous malignant lymphoma.
Histologic and immunohistochemical analysis revealed the correct diagnosis. Leukaemia cutis refers to the infiltration of the skin with leukaemia cells. Older terms, such as lymphocytoma benigna cutis, lymphocytoma of the. Lymphocytoma cutis, or benign reactive lymphoid hyperplasia, is an inflammatory skin lesion that mimics clinically and histologically malignant lymphoma.
In 1922, when discussing bibersteins2 case, jadassohn commented that his original. Photodynamic therapy however has been tried for lymphocytoma cutis. Lymphocytoma cutis is a subtype of cutaneous pseudolymphoma involving the face, chest, and upper extremities. Lymphocytoma definition of lymphocytoma by medical. Skin involvement leukemia cutis occurs in 5% with cml, 8% with cll, 10% with monocytic leukemia myeloid leukemia with monocytic differentiation more commonly involves the skin than other types of myeloid leukemia usually is abnormal peripheral blood count at diagnosis. Lymphocytoma cutis is a rare cutaneous eruption that may possess clinical and histologic features resembling malignant lymphoma. Various synonyms have been introduced and several terms are still nowadays used to describe psls of the skin. We studied retrospectively 108 biopsies from 106 patients male. The disease is rarely seen in india and may cause diagnostic difficulties for dermatologist residing in parts of the world that are not. Lymphocytoma definition of lymphocytoma by medical dictionary.
Leukemia cutis is a local manifestation of an underlying systemic disease. Cd123positive plasmacytoid dendritic cells in primary. Search icd10 code lookup find diagnosis codes icd10cm and procedure codes icd10pcs by disease, condition or icd10 code. Lymphocytoma cutis lc is considered as the stereotypical example of the cutaneous b. Aug 14, 2019 this example of lymphocytoma cutis shows a localized, erythematoustobrown, illdefined plaque. In 1922, when discussing bibersteins 2 case, jadassohn commented that his original patient was still living, that the skin lesions were unchanged and that no. Files are available under licenses specified on their description page. No fever, malaise, or other systemic symptoms were reported. What is lymphocytoma cutis lymphocytoma cutis is a rare pseudolymphoma that has also been known as cutaneous lymphoid hyperplasia or lymphadenosis benigna cutis. The remit of this chapter, which is set out as below, is to provide a brief overview into the some of the more commonly recognised conditions. Leukemia cutis may occur within established scars and within recent areas of trauma, including hickman catheter sites, sites of burns, decubitus ulcers, 38 herpes simplex virus hsv scars, or zoster scars.
About 1 items found relating to lymphocytoma benign cutis. It was reported as a case of pseudoleukemic infiltration of the skin. Lymphoma and leukaemia can present in the skin as a primary cutaneous disorder ie occur in the skin with no evidence of disease elsewhere at the time of diagnosis, a secondary infiltration or indirectly eg as pruritus secondary to hodgkins lymphoma. Various stimuli can induce lymphocytoma cutis, but in most cases the cause is not known. Several synonyms have been used for lymphocytoma cutis including lymphadenosis benigna cutis, cutaneous lymphoplasia, cutaneous lymphoid hyperplasia and pseudolymphoma of spieglerfendt. Rockoff, please help me with some of your experience. Our purpose was to find a good method to treat patients with lymphocytoma cutis. Clusters of cd123positive pdc were recently found by immunohistochemistry in all pcmzl cases 23 of 23 cases, 100%. I initially feared nodular melanoma but initial biopsy results suggest lymphoma. Mar 01, 2004 lymphocytoma cutis lc is considered as the stereotypical example of the cutaneous b. The disease is rarely seen in india and may cause diagnostic difficulties for dermatologist residing in parts of the world that are not endemic for lyme disease. Nov 28, 2012 lymphocytoma cutis, or spieglerfendt sarcoid, is classed as one of the pseudolymphonas, 1 referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas.
Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns, a condition of the skin characterized by skin lesions that clinically resemble mycosis fungoides. Borrelia burgdorferi infection and cutaneous lyme disease, mexico. Lymphocytoma cutis primary care dermatology society uk. Benign lymphocytoma cutis definition of benign lymphocytoma. As the clinical differential diagnosis includes lymphoma, a biopsy is essential. Lymphocytoma medical definition merriamwebster medical. Lymphocytomatosis medical definition merriamwebster.
Rather, lymphocytoma cutis is a response to a variety of known and unknown stimuli that results in the accumulation of lymphocytes and other inflammatory cells in a localized region. Lymphocytoma cutis of the shoulder, composed of fleshcolored or erythematous nodules in small groups. Covering all aspects of skin disease from basic science through pathology and epidemiology to clinical practice, the text is recognized for its unparalleled coverage of diagnosis. Various antigenic stimuli can induce these lesions. I used your resource and was able to come up with a differential diagnosis and convince my attending to do a skin biopsy and it turned out to be the diagnosis i had suggested. Typically, the lesions are small, superficial, translucent, firm, nontender, pinkishred. She was very impressed by my use of a valuable resource, and she tells the story to all the faculty. Lymphoma or lymphocytoma cutis dermatology medhelp. A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. All structured data from the file and property namespaces is available under the creative commons cc0 license.
Literature on aleukemic leukemia cutis is limited, but because diagnosis of leukemia cutis portends poor prognosis in acute leukemia, the treatment should be directed at eradicating the leukemic clone by using aggressive systemic chemotherapy and stem cell. Two 36 and 54 years of age had erythema migrans lesions, and 2 9 and 34 years of age had borrelial lymphocytoma lesions. After 5 sessions, satisfactory improvement was observed. It can be induced by various antigenic stimuli including arthropod bites, vaccination, and drugs among others. In 1923, bilerstein coined term lymphocytoma cutis term lymphadenosis benigna cutis was introduced by bafverstedt in 1943 in 1967, lever introduced term pseudolymphoma of spiegler and fendt subsequently,caro and helwig in 196. Excised one month prior to presentation with recurrence. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
A tendency for vertical orientation of the lesion with the infiltrate being topheavy denser infiltrate in the upper dermis as compared to the lower dermis. This study suggests the borrelia burgdorferi infection is. There may be isolated lesions or regionalareas of localization. Lymphocytoma cutis lc is one of the most common types of cutaneous b cell pseudolymphoma. Cutaneous lymphoid hyperplasia refers to a groups of benign cutaneous disorders characterized by collections of lymphocytes, macrophages, and dendritic cells in the skin 725 conditions included in this groups are 725 cutaneous lymphoid hyperplasia with nodular pattern, a condition of the skin characterized by a solitary or localized cluster of asymptomatic erythematous to violaceous. This example of lymphocytoma cutis shows a localized, erythematoustobrown, illdefined plaque. Histologic features help differentiate lymphocytoma cutis from cutaneous malignant lymphoma. In each patient the lesions responded well to cryosurgery. Rooks textbook of dermatology is the most comprehensive work of reference available to the dermatologist. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. Atypical location of lymphocytoma cutis in a child atypical location of lymphocytoma cutis in a child amschler, katharina. Plasma cell leukemia cutis has been reported to occur in recent puncture sites. Borrelial lc occurs most commonly in areas endemic for ixodes ricinus tick in europe, and it is rare in north america.
Lymphocytoma cutis cutaneous lymphoid hyperplasia, cutaneous bcell pseudolymphoma, spieglerfendt sarcoid is an entity encompassing a spectrum of benign bcell lymphoproliferative diseases that share clinical and histopathologic features. Jan 26, 2011 i did a literature search for either uvb or puva being used for lymphocytoma cutis and there is not a single article or case report in the world. Lymphoma and leukaemia cutaneous presentations primary. Here we report a unique case of an atypical location of lymphocytoma cutis in a 3. In about may, i noticed a what i thought was a pimple form on my right cheek high, under eye. In 1906 jadassohn1 presented before the ninth german dermatological congress the first case of what was later to be known as lymphocytoma cutis. Lymphocytoma cutis is the name for a group of skin disorders defined as. For the first time the concept of psl pseudomalignancy had been introduced by m.
Cutaneous pseudolymphoma fitzpatricks dermatology, 9e. Redirect this redirect does not require a rating on the projects quality scale. Spieglerfendt sarcoid lymphocytoma cutis is a benign lymphocytic tumor typically presenting as an illdefined violaceous nodule or nodules that can enlarge slowly into large plaques. Atypical location of lymphocytoma cutis in a child, pediatric. I did a literature search for either uvb or puva being used for lymphocytoma cutis and there is not a single article or case report in the world. Lymphocytoma cutis is known to simulate lymphoma, as reflected primarily by the histologic findings. This photograph of lymphocytoma cutis caused by an arthropod bite shows an erythematous scaling patch of the scalp with localized secondary alopecia. Welldemarcated plaque, 4 x 5 cm in size consisting of grouped erythematous shiny papules and nodules. Jul 31, 20 dermatopathology reference describes lymphocytoma cutis spiegler fendt sarcoid histopathology including histologic features and provides links to additional medical references. Clinical diagnosis was supported with histologic, serologic, and molecular tests. Lymphocytoma cutis skin lymphoma americorps health blog. A diagnostic dilemma lymphocytoma cutis lc is one of the most common types of cutaneous b cell pseudolymphoma.
It is a process that simulates a cutaneous lymphoma blood cell cancer developing in the skin, but it behaves in a harmless manner. From june 1999 to october 2000, 4 patients in mexico city had clinical manifestations suggestive of lyme disease 5,6. Lymphocytoma cutis is a rare pseudolymphoma that has also been known as cutaneous lymphoid hyperplasia or lymphadenosis benigna cutis. Cutaneous pseudolymphomacpl was first described under the term sarcomatosis cutis by kaposi in 1891. Localized lymphocytoma cutis, the most common form, may occur in both children and adults and has a short course. The areas of predilection are the face,ear lobes,nipples,vulva,and scro tum. Sep 01, 20 lyme borreliosis is a common infectious disease that can affect myocardial muscle or the central nervous system if not treated at an early stage. The leukaemia may be acute or chronic, due to proliferation of lymphocytes or more commonly, myeloid cells the neutrophils. A series of five patients successfully treated with cryosurgery avery s.